tamoxifen side effects

As monotherapy adults and children older tamoxifen side effects than 2 years of age with epilepsy (including in patients with newly-diagnostic Rowan epilepsy). In the combined therapy: adults and children older than 2 years with partial or generalized tonic-clonic seizures and for the treatment of seizures in the background of Lennox-Gastaut syndrome.


Prevention of migraine in adults. The use of the drug Topamax ® has not been studied for the treatment of acute migraine attacks.


Hypersensitivity to any component of this medication, children up to 2 years.

The use of topiramate for migraine prophylaxis is contraindicated during pregnancy and in women with childbearing potential stored not using reliable methods of contraception.

Pregnancy and lactation

Topiramate showed teratogenic properties in mice, rats and rabbits. In rats, topiramate crosses the placental barrier.

Special-controlled studies in which tamoxifen side effectsbe used for the treatment of pregnant women have been conducted. Topiramate may cause harm to the fetus when used in pregnant women. These accounting pregnancies indicate that infants exposed to topiramate in utero during the first trimester of pregnancy have an increased risk of congenital malformations (eg, craniofacial defects, such as cleft lip or palate, hypospadias, and anomalies of the various body systems). These malformations were recorded as the topiramate monotherapy or when used as part of polytherapy.

Data from one of the registers of pregnancies have shown that topiramate monotherapy incidence of major congenital malformations is increased approximately 3-fold compared with the comparison group, not to take anti-epileptic drugs.

Furthermore, it is shown that the risk of teratogenic effects associated with the reception of antiepileptic drugs in the above case of combined therapy, than in the case of monotherapy.

Compared with patients not taking antiepileptic drugs tamoxifen testosterone, accounting data of pregnancy in monotherapy show an increase in the likelihood of low birth weight (less than 2500 g). One of the registers pregnancies showed an increase in the relative number of babies aborted for their gestational among infants exposed to topiramate in utero. Long-term effects are not defined tamoxifen side effects. The reason for reducing the body weight has not been established at birth .

During therapy with topiramate woman saved childbearing potential must use reliable methods of contraception.

The use of the drug Topamax ® during pregnancy in women with uncontrolled epilepsy is justified only in cases where the potential benefits of the drug to the mother outweighs the potential risk to the fetus.The use of topiramate for migraine prophylaxis is contraindicated during pregnancy and in women with childbearing potential stored not using reliable methods of contraception. In the treatment and counseling of women with childbearing potential, the attending physician must weigh the risk and benefit ratio of treatment and consider alternative treatment options. If tamoxifen side effectsis used during pregnancy, or if the patient becomes pregnant while taking this drug, it should be warned about the potential risk to the fetus.

A limited number of observations of patients suggests that topiramate is excreted in breast milk in women, so the doctor has to take a decision on the refusal from breastfeeding or stopping treatment.

This entry was posted in supplements online and tagged . Bookmark the permalink.